Bio
I am a passionate Pharmacometrician and Senior Scientist with a deep love for science and science communication. I hold a PhD in Biomedical Sciences from the University of Connecticut. My research includes pharmacometric modeling and simulation across various therapeutic areas such as cancer, diabetes, and COVID-19. My work employs diverse techniques including Quantitative Systems Pharmacology (QSP), Physiologically-Based Pharmacokinetics (PBPK), Bayesian inference, and machine learning.
I am proficient in programming languages such as Julia and R, which I use extensively in my research and modeling work. Beyond my professional expertise, I am deeply interested in the intersection of science, philosophy, and religion, and how these fields can inform and enrich each other. Additionally, I have a strong interest in mathematics, its history, and its profound impact on daily lives and human civilization. I am fascinated by how mathematical principles and numbers shape our world and contribute to solving complex scientific problems.
I am also an author of both fiction and nonfiction, with two books published in Arabic and currently in the process of publishing them in English. My writing reflects my passion for science and my desire to communicate complex ideas in an accessible and engaging way.
Key research interests
- Pharmacometrics: Quantitative systems pharmacology (QSP), physiologically based pharmacokinetics (PBPK), population pharmacokinetics/pharmacodynamics (PKPD), Bayesian hierarchical PKPD modeling, merging pharmacometrics with machine learning
Teaching
I serve as an adjunct professor at both the University of Connecticut and Indiana University
Books
The Dreamers (Arabic) https://www.jarir.com/arabic-books-jbb6720na092.html
Numbers that Dazzled the World (Arabic) https://www.jarir.com/arabic-books-522887.html?country=us
Selected papers
Elmokadem A, Wiens M, Knab T, Utsey K, Callisto S, Kirouac D. Hierarchical deep compartment modeling: A workflow to leverage machine learning and Bayesian inference for hierarchical pharmacometric modeling. Clinical and Translational Science, October. https://doi.org/10.1111/cts.70045.
Chigutsa E, Jordie E, Riggs M, Nirula A, Elmokadem A, Knab T, and Chien JY. A Quantitative Modeling and Simulation Framework to Support Candidate and Dose Selection of Anti-SARS-CoV-2 Monoclonal Antibodies to Advance Bamlanivimab into a First-in-Human Clinical Trial. Clinical Pharmacology & Therapeutics, October. https://doi.org/10.1002/cpt.2459. This manuscript received the “Outstanding Research Manuscript Award” from the International Society of Pharmacometrics (ISoP) in October 2022.
Professional affiliations
International Society of Pharmacometrics (ISoP)
American Society of Clinical Pharmacology and Therapeutics (ASCPT)
Personal life
I am a father and a husband who enjoys the routine scientific-philosophical-religious-political discussions with my family. My wife is incredibly supportive and loving, always encouraging me in my pursuits and standing by my side through thick and thin. We share a deep bond and a mutual passion for exploring life’s big questions together.
Video game time with my son is also something I cherish. It’s our special way of bonding and having fun, whether we’re teaming up to conquer virtual worlds or just laughing at our in-game mishaps. These moments are priceless and bring a lot of joy to our lives.