Papers

2024

Elmokadem A, Wiens M, Knab T, Utsey K, Callisto S, Kirouac D. Hierarchical deep compartment modeling: A workflow to leverage machine learning and Bayesian inference for hierarchical pharmacometric modeling. Clinical and Translational Science, October. https://doi.org/10.1111/cts.70045.

2023

Elmokadem A, Zhang Y, Knab T, Jordie E, Gillespie WR. Bayesian PBPK Modeling using R/Stan/Torsten and Julia/SciML/Turing.jl. CPT: Pharmacometrics & Systems Pharmacology, January. https://doi.org/10.1002/psp4.12926.

2021

Chigutsa E, Jordie E, Riggs M, Nirula A, Elmokadem A, Knab T, and Chien JY. A Quantitative Modeling and Simulation Framework to Support Candidate and Dose Selection of Anti-SARS-CoV-2 Monoclonal Antibodies to Advance Bamlanivimab into a First-in-Human Clinical Trial. Clinical Pharmacology & Therapeutics, October. https://doi.org/10.1002/cpt.2459. This manuscript received the “Outstanding Research Manuscript Award” from the International Society of Pharmacometrics (ISoP) in October 2022.

Bruno CD, Elmokadem A, Housand C, Jordie EB, Chow C, Laughren TP, and Greenblatt DJ. Impact of Obesity on Brexpiprazole Pharmacokinetics: Proposal for Improved Initiation of Treatment. Journal of Clinical Pharmacology, August. https://doi.org/10.1002/jcph.1947.

Elmokadem A, Bruno CD, Housand C, Jordie EB, Chow C, Lesko LJ, and Greenblatt DJ. Brexpiprazole Pharmacokinetics in CYP2D6 Poor Metabolizers: Using Physiologically Based Pharmacokinetic Modeling to Optimize Time to Effective Concentrations. Journal of Clinical Pharmacology, July. https://doi.org/10.1002/jcph.1946.

Johnston CK, Eudy-Byrne RJ, Elmokadem A, Nock V, Marquard J, Soleymanlou N, Riggs MM, and Liesenfeld KH. A Model-Informed Drug Development (MIDD) Approach for a Low Dose of Empagliflozin in Patients with Type 1 Diabetes. Pharmaceutics, April. https://doi.org/10.3390/pharmaceutics13040485.

2020

Utsey K, Gastonguay MS, Russell S, Freling R, Riggs MM, and Elmokadem A. Quantification of the Impact of Partition Coefficient Prediction Methods on PBPK Model Output Using a Standardized Tissue Composition. Drug Metabolism and Disposition, July. https://doi.org/10.1124/dmd.120.090498. The paper was listed among the “Papers Worth Reading” by the International Society of Pharmacometrics (ISoP) newsletter issued in September 2020 https://doi.org/10.1124/dmd.120.090498.

2019

Perkins BA, Soleymanlou N, Rosenstock J, Skyler JS, Laffel LM, Liesenfeld KH, Neubacher D, Riggs MM, Johnston CK, Eudy‐Byrne RJ, Elmokadem A, George JT, Marquard J, and Nock V. Low‐dose empagliflozin as adjunct to insulin therapy in type 1 diabetes: A valid modelling and simulation analysis to confirm efficacy. Diabetes, Obesity and Metabolism, December. https://doi.org/10.1111/dom.13945.

Elmokadem A, Riggs MM, and Baron KB. Quantitative Systems Pharmacology and Physiologically-Based Pharmacokinetic Modeling With mrgsolve: A Hands-On Tutorial. CPT: Pharmacometrics & Systems Pharmacology, October. https://doi.org/10.1002/psp4.12467.

Ji Y and Elmokadem A. Single-Molecule Localization Microscopy as Nonlinear Inverse Problem. Proceedings of the National Academy of Sciences of the United States of America, September. https://doi.org/10.1073/pnas.1912634116.

2015

Elmokadem A and Yu J. Optimal Drift Correction for Superresolution Localization Microscopy with Bayesian Inference. Biophys J. 109(9), 1772-1780. https://doi.org/10.1016/j.bpj.2015.09.017